As such, its inhibition in the dorsal striatum leads to a loss of functional glutamatergic synapses.46 CAMK2A protein expression was previously found decreased in the hippocampus of fully symptomatic 10-week-old R6/2 Huntington’s disease mice.10 Here, while our phosphorylation data points towards an inactivation of the enzyme, we found no differences in CAMK2A protein expression between Huntington’s disease and WT mice. Here, CAMK2A is linked to Huntington disease.