CAMK2A and juvenile Huntington disease: We found that CAMKK2 phosphorylation at Serine 495 and CAMK2A phosphorylation at Threonine 337 impaired their calcium-calmodulin activation.19,20 Here, we observed a down-phosphorylation at these sites in Huntington’s disease compared with WT mice, which does not directly translate into an increased activity of the enzymes but might increase their probability to be activated.