The increased phosphorylation of PI4KB, as seen in Huntington’s disease mice, induces its localization in nuclear speckles.21 PI4KB functions as a signalling molecule, responsible for the phosphorylation of phosphatidylinositol into the second messenger phosphatidylinositol biphosphate, later phosphorylated into triphosphate. Here, PI4KB is linked to Huntington disease.