RAF1 and juvenile Huntington disease: The increased phosphorylation of PI4KB at Serine 511 observed in Huntington’s disease mice, has shown to induce a localization of the kinase in the nucleus.21 Also, Serine 621 phosphorylation on RAF1, found upregulated in Huntington’s disease mice, has been shown to increase the protein’s stability and prevent it from being degraded in the proteasome22 (Table 1).