Most of the proteins altered in the hippocampus between Huntington’s disease and WT mice in SH were calcium-dependent and/or involved in calcium homeostasis, including wolframin (WFS1), hippocalcin (HPCA), inositol-triphosphate kinase A (ITPKA), Ras guanyl-releasing protein 1 (RASGRP2) and protein kinase C (PRKCB). The gene discussed is RASGRP1; the disease is juvenile Huntington disease.