This finding is in contrast to our recent study which found an increased tau phosphorylation in the cortex of 8-week-old R6/1 Huntington’s disease mice when housed in SH conditions.8 However, this could reflect a potential beneficial effect of EE in Huntington’s disease mice, whereby EE could have a different effect on WT versus Huntington’s disease mice. Here, MAPT is linked to juvenile Huntington disease.