There are also no statistically significant correlations with CSF amyloid beta and CAD-PRS or AD-PRS; presumably, we did not find evidence for an association with AD-PRS because amyloid biomarkers are mainly influenced by the APOE-e4 genotype.25 Moreover, the analysis was conducted within disease groups and not between disease groups, where stronger differences are known to exist.47 This evidence concerns the gene APOE and Alzheimer disease.