APOE and early-onset autosomal dominant Alzheimer disease: Investigators have shown that APOE’s effect on Alzheimer’s disease is greater in older cohorts and suggest that variants outside of APOE could contribute to Alzheimer’s disease in older persons.55 As APOE has been considered a target for both the treatment of coronary heart disease and Alzheimer’s disease, these two pathologies may both be affected by similar pathways.