Alzheimer’s disease-PRS (AD-PRS) over varying P-value selection thresholds has effectively discriminated between Alzheimer’s disease cases and controls,21 been used as a predictor of conversion from mild cognitive impairment (MCI) to Alzheimer’s disease,22 been linked to inflammatory biomarkers,23 CSF amyloid beta levels,24 CSF tau levels,25 hippocampal volume,26 cortical thickness27 and age of onset of Alzheimer’s disease.28 AD-PRS-related work has been recently reviewed by.29 Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.