Interestingly, compared to the control group, c-Jun and PD-L1 protein levels showed a significant decrease upon AIL or anti-PD-L1 mAb treatment, which was further suppressed by combination treatment with AIL and anti-PD-L1 mAb in tumor tissues (Fig. 5F and Additional file 2: Fig. S8D). The gene discussed is JUN; the disease is neoplasm.