In line with the RT-induced cell senescence, treatment with Nutlin-3, a small molecule compound that acts by disrupting the p53-MDM2 interaction and thus p53 stabilization to enhance tumor suppression, at concentrations of 5–10 μM efficiently sensitize PCa cells to clinically-relevant 2 Gy dose of irradiation by induction p53-dependent mediated cellular senescence [54, 58]. Here, TP53 is linked to neoplasm.