As shown (Fig. 4I and Fig. S4G, H), KIF23 changed markedly in tumor tissues corresponding to adjacent tissues among the 7 candidate genes and the potential ac4C motif in the modified region (chr15:69 448 127–69 448 397) on KIF23 mRNA 3’UTR region might be ‘CUUCUCCAG’. The gene discussed is KIF23; the disease is neoplasm.