As the only currently known ‘writer’ protein for ac4C modification, the importance of NAT10, about its involvement in cancers, especially those that exhibit its facilitatory effects, such as gastric cancer, bladder cancer, hepatocellular carcinoma, multiple myeloma, and non-small cell lung cancer, has been increasing highlighted [8, 12, 23–25]. The gene discussed is NAT10; the disease is non-small cell lung carcinoma.