Similarly, a 10-year observational follow-up of people with type 2 diabetes [76] who were originally randomized to intensive glycaemic control had significant long-term reductions in myocardial infarction (15 to 33%) and in all-cause mortality (13 to 27%) depending on whether sulfonylurea or insulin or metformin was given as initial pharmacotherapy. Here, INS is linked to type 2 diabetes mellitus.