Given promoter hypomethylation of oncogenes has been considered as a tumor initiation and development promotive factor, it could result in gene overexpression, and downstream signaling pathways activation [32, 33], our related results showed that ZBTB9 promoter methylation was evidently lower in tumor tissues compared to adjacent normal tissues, and the genomic alteration was another potential reason for its upregulation. Here, ZBTB9 is linked to neoplasm.