Because we ruled out any difference in the proliferative rate, cell cycle and apoptosis of pancreatic cancer cells in vitro or an effect on tumor growth in immunocompromised mice, these data indicate that Slc4a4 targeting in cancer cells imposes a cell-extrinsic alteration of the TME that hinders tumor growth and metastasis through the immune system. The gene discussed is SLC4A4; the disease is neoplasm.