GZMB and cancer: When ovalbumin-expressing cancer cells were cocultured with OT-I T cells, we observed that OT-I T cells were able to kill more sgSlc4a4 cells than sgNT cancer cells (Fig. 5k, control), together with an increase in cytotoxicity markers such as IFNγ and granzyme B (GZMB; Extended Data Fig. 5j).