Similarly, staining for SLC4A4 in mice displayed a positive signal in the cancer cell compartment of orthotopic KPC tumors (obtained from the KrasG12D; p53LSL.R172H; P48:Cre transgenic mouse model) and in ducts and ductules of the surrounding pancreatic tissue (Extended Data Fig. 1i,j). Here, SLC4A4 is linked to cancer.