The major role of CD8+ T cell activation after Slc4a4 targeting was further supported by the observation that CD8+ T cell depletion (Extended Data Fig. 6b–e) completely abolished the difference in tumor growth in the subcutaneous Panc02 and orthotopic KPC1 and KPC3 models (Fig. 5m–o and Extended Data Fig. 6f). Here, SLC4A4 is linked to neoplasm.