However, as in the other models, CD8+ T cells were more located at tumor center after sgSlc4a4 targeting and were substantially more abundant in the periphery as well (Fig. 5j and Extended Data Fig. 5i), suggesting that although the total number of CD8+ T cells did not change, these cells were better suited to enter into the tumor, and they were more activated. The gene discussed is CD8A; the disease is neoplasm.