IFNG and cancer: Consistently, in vitro analysis of bone marrow-derived macrophages (BMDMs) cocultured with sgNT and sgSlc4a4 Panc02 cells did not show any differences in the polarization markers (Extended Data Fig. 7h,i), but the presence of sgSlc4a4 cancer cells, along with different concentrations of IFNγ (predominantly secreted by T cells39,40) sensitized BMDMs to an M1-like phenotypic switch (Fig. 6m).