RNA-seq of CD34+ progenitor MUTZ-3 cells after MECOM editing revealed significant depletion of MECOM down genes and significant enrichment of MECOM up genes (Fig. 8g, Extended Data Fig. 8f and Supplementary Table 7), Additionally, MECOM perturbation in HNT34 AML cells led to significant depletion of MECOM down genes and significant enrichment of MECOM up genes (Fig. 8h), revealing the conservation of this gene regulatory network in multiple AML contexts. The gene discussed is MECOM; the disease is acute myeloid leukemia.