Golgi transport 1 B (GOLT1B) as a vesicle transporter that participates in protein trafficking in cytoplasm increases PD-L2 expression and facilitates PD-L2 membrane localization in colorectal cancer to promote apoptosis of T cells and decreases IFN-γ expression, which in turn promotes migration and invasion in CRC [30]. The gene discussed is PDCD1LG2; the disease is colorectal carcinoma.