Finally, and since proinflammatory stimuli trigger iron deposition in microglia from G2019S-LRRK2 knockin as compared to control mice [72], it is also possible that persistent neuroinflammation [73] contributes to the differences in iron and copper content in human G2019S-LRRK2 PD brains as determined here. Here, LRRK2 is linked to Parkinson disease.