To further confirm that [68Ga]Ga-FAPI uptake assesses current molecular fibroblast activity, we analyzed associations of [68Ga]Ga-FAPI-04 uptake at baseline with changes of clinical parameters of SSc-MF on follow-up: left ventricular contractility (EF), changes of ECG morphology, and serum Nt-pro-BNP levels in all patients available for follow-up:. The gene discussed is NPPB; the disease is systemic sclerosis.