IGF2 and neoplasm: Lymphangiogenesis occurs in response to inflammation, wound healing or tumor regression, and LECs are affected by several types of lymphangiogenic factors such as VEGF-A, VEGF-C, VEGF-D, FGF-2, HGF, insulin-like growth factor-1 (IGF-1), IGF-2, angiopoietin-1 (Ang-1), Ang-2 and platelet-derived growth factor-bb (PDGF-BB)19.