Down-regulated pathway terms included ‘TCRA pathway’, ‘Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex’, ‘TP53 activity’, and ‘PD1 signalling’, suggesting T cell activation in more severe COVID-19 (Fig. 3b, c, Supplementary Data 1g). The gene discussed is TP53; the disease is COVID-19.