IFNG and infection: Examples of marked changes in gene expression between pre-infection and acute infection in the Wave 2 cohort included components of ‘Immunoregulatory interactions between a lymphoid and a non-lymphoid cell’ pathway term (e.g., SIGLEC1, SIGLEC9, SELL, all increased) and ‘Development and heterogeneity of the ILC family’ (e.g., IFNG, GATA3, RORA, all decreased) (Fig. 2b).