The reduction in FADD levels using siRNA partially prevented basal and/or TRAIL-induced IL-8 release in A549 and H460 (Fig. 5I, J, Fig. S5F–I), but some toxicity was observed with the siRNA and particularly when employing a dominant negative form of FADD (not shown), which may be due to necroptosis or to mitotic functions of FADD in Ras-driven NSCLC [42]. Here, CXCL8 is linked to non-small cell lung carcinoma.