Loomba et al. found that a set of 152 differentially methylated CpG islands in the peripheral blood-DNA of NASH patients correlate with the severity of hepatic fibrosis and that this DNA methylation signature is associated with the age-related acceleration of NASH in patients.74 However, demethylation of histone H3K9 on the promoter of PPARγ2 may induce hepatic steatosis through upregulation of hepatic PPARγ2 expression.292. Here, PPARG is linked to Hepatic steatosis.