PPARG and Hepatic fibrosis: Loomba et al. found that a set of 152 differentially methylated CpG islands in the peripheral blood-DNA of NASH patients correlate with the severity of hepatic fibrosis and that this DNA methylation signature is associated with the age-related acceleration of NASH in patients.74 However, demethylation of histone H3K9 on the promoter of PPARγ2 may induce hepatic steatosis through upregulation of hepatic PPARγ2 expression.292