The expression of p16(INK4a) and the number of senescent β-cells are increased in pancreatic islets.273 The loss of β- cell mass leads to fasting hyperglycemia and impairs mitochondrial membrane integrity.273 In a cancer-resistant mouse model, telomerase reverse transcriptase overexpression has been found to improve glucose tolerance.274. This evidence concerns the gene CDKN2A and Hyperglycemia.