TBCE and Hepatic fibrosis: This suggests that the cellular stress signature probably drives both the death of resident KCs and the generation of monocyte-derived KCs.328–330 In addition, monocyte-derived KCs localize to fibrotic areas in the liver and localize close to desmin+ hepatic stellate cells (HSCs) during NASH in mice, suggesting that they may participate in hepatic fibrosis.331