CD8A and neoplasm: For example, IL-6 causes the recruitment of myeloid-derived suppressor cells to the tumor microenvironment,494 and myeloid-derived suppressor cells not only blocks IL-1-mediated cellular senescence, but also reduces immune surveillance through the suppression of antitumor cells such as CD8+ T cells and NK cells.495 Hepatocytes with NrasG12V-induced senescence attract a subpopulation of CCR2+ myeloid cells by secreting CCL2, and these cells bind to NK cells, ultimately blocking tumor immunosurveillance.496