α-Syn oligomers can spread from cell-to-cell throughout the brain, thereby aggravating the progression of PD.219 Some studies have suggested that another potential mechanism for the pathological spread of α-syn is the binding of misfolded prefibrils to lymphocyte activation gene 3 (LAG3), which initiates the endocytosis, delivery, and cytotoxicity of α-syn prefibrils.220. This evidence concerns the gene LAG3 and Parkinson disease.