While being vital for kidney glomerular development and function,113 mutant mice can also lack one or both kidneys completely.114 Mutations in LAMA5 have been detected in one patient with CAKUT leading to its classification as a disease candidate gene.5 We also noticed that iRECs reprogrammed with HNF1B R295C were more adherent and showed an altered morphology in comparison with iREC generated with WT HNF1B (Supplemental Figure 6B). This evidence concerns the gene LAMA5 and congenital anomaly of kidney and urinary tract.