Indeed, this “priming” of RIG-I signaling by interferon has been proposed to play a central role in antiviral signaling.27,28 However, naive and unprimed cells must be able to respond to viral infection and trigger a robust immune response or an initial infection would escape detection.17,29 Therefore, the role of downstream, interferon-induced RIG-I expression remains unclear. This evidence concerns the gene RIGI and viral infectious disease.