Finally, to assess the potential human relevance of our findings, we reanalyzed a scRNA-seq dataset from human idiopathic pulmonary fibrosis (IPF; n=31) patients and control (n=19) lung donors.49 In IPF, MFs express strong pro-fibrotic gene programs and contribute to the progression of the disease.49 First, we identified MFs in the dataset (expressing e.g., CD74 and MRC1), which comprised 7 distinct clusters, one of which was a proliferating MF cluster (cluster 4; Figure 7C and D). This evidence concerns the gene MRC1 and idiopathic pulmonary fibrosis.