IL4 and allergic disease: We focused on two major components of the M2-induced polarization program, Mgl2 and Retnla (involved in the pathogenesis of multicellular parasite infections, allergic reactions, and asthma), as demonstrating either G2/M- or G1-biased IL-4-induced expression patterns and enhancer activities, respectively.38–40 First, we validated the CC-phase-biased expression of both genes (Figure 4D and F).