NUC-7738 significantly reduced the expression of CD44 in both OCI-AML3 and HL-60 cells, suggesting that not only does the inhibition of β-catenin by NUC-7738 result in inhibition of its downstream target CD44, but also that NUC-7738 could potentially inhibit homing of AML cells to microenvironmental niches and relieve the primitive phenotypes of such cells. The gene discussed is CD44; the disease is acute myeloid leukemia.