APOE and Alzheimer disease: Recently we identified a 151 amino-terminal fragment of ApoE4 (nApoE41-151) that localized within the nucleus of both neurons and microglia cells of the human AD brain [18] and in vitro, we demonstrated this fragment is taken up by BV2 microglia cells, traffics to the nucleus and leads to the upregulation of thousands of genes, many of which associated with microglia activation and inflammation [16, 28].