Pearson correlation analyses of TGCA data (Fig 1C) showed that AIF-1 expression was significantly positively correlated with CD68 expression (a macrophage marker) in NSCLC (r = 0.600, P < 0.001), lung SCC (r = 0.590, P < 0.001) and lung adenocarcinoma (r = 0.600, P < 0.001). This evidence concerns the gene AIF1 and lung adenocarcinoma.