Additionally, a loss of hepatic CYP activity in hepatic P450 oxidoreductase (POR)-null mice led to steatosis and the induction of Cyp2b, including Cyp2b10, primarily through CAR activation [5], indicating a role for CAR in recognizing and Cyp2b in metabolizing hepatic lipids. This evidence concerns the gene CYP2B6 and steatosis.