Concerning the VER-155008 effect on mRNA expression, VER-155008 reportedly enhances toll-like receptor 5 (TLR5) mRNA expression but reduces TLR5 cell surface expression in human myeloid leukemia THP-1 cells, suggesting that suppressing the HSP70 inhibitor-related chaperone function could prevent mature TLR5 traffic from the endoplasmic reticulum (ER) to the cell surface [33]. This evidence concerns the gene TLR5 and myeloid leukemia.