We show that IGF2BP3 is induced predominantly in kidney tubular epithelium in all CKD models tested, including UUO, IRI, ADR, and Ang II infusion, as well as in human kidney biopsies of patients with various CKDs such as DN, CTIN, LN, IgAN, FSGS, and MN. Here, IGF2BP3 is linked to focal segmental glomerulosclerosis.