APOE and Alzheimer disease: Consistent with our findings, previous studies have shown that a PRS for AD derived from European GWASs accurately estimated the dementia risk among non-Hispanic Black8,9 and Caribbean Hispanic individuals.10 In our multivariable logistic model, PRS was associated with the AD dementia risk independent of the APOE ɛ4 carrier status, which was replicated in the independent data set.