ZMYND8 is a histone reader mainly targeting to the dual marks H3K4me1 and H3K14ac and that the signature H3K4me1-H3K14ac manifests as a repressive signature for metastasis-linked genes; it has been shown that an anti-invasive factor against prostate cancer metastasis mediates downregulation of metastasis-linked genes [110]. This evidence concerns the gene ZMYND8 and Familial prostate cancer.