We have recently reported that the expression of BLU/ZMYND10 induces a repressive histone mark trimethylated lysine 9 of histone 3 (H3K9me3) in lung cancer line H1299 or hepatoblastoma HepG2, both cell lines are absent of BLU expression during in vitro culture [95]. The gene discussed is ZMYND10; the disease is lung carcinoma.