PRKN and Parkinson disease: Supporting this, we found that stable O/E of familial PD-associated, E3 ubiquitin ligase-deficient Parkin T240R (23,36) induced a significant increase in FBXW7β protein levels and prevented Parkin-induced upregulation of nSREBP2 and LPL in SH-SY5Y cells (Supplementary Material, Fig. S7).