Interestingly, several genetic risk factors for PD (e.g. SNCA, GBA and SREBF1) are associated with lipid homeostasis, suggesting a potential involvement of lipid dysregulation in PD pathogenesis (5–8).Consistent with this notion, several studies have reported abnormal lipid metabolism in brain tissues from PD patients and various experimental models of PD. Here, SREBF1 is linked to Parkinson disease.