A murine model of NPC1 (Npc1−/−, BALB/cNctr-Npc1m1N/J) carries a spontaneous loss of function mutation in the Npc1 gene and develops classical NPC neurological disease, including the loss of Purkinje cells and an almost disease-free spinal cord. This evidence concerns the gene NPC1 and nasopharyngeal carcinoma.