Notably, within the context of a lysosomal disease, overexpression of IL-1Ra or abrogation of Il-1R1 in a mouse model of MPSIIIA halted the development of pathological hallmarks, including a striking reduction in reactive astrocytes (31), which is evidence of interleukin-1 being a driver of astrogliosis (84). Here, IL1R1 is linked to Lysosomal disease.