An idea supported by the recent discovery that the canonical inflammasome Nlrp3 (nucleotide-binding leucine-rich repeat receptor family member pyrin-domain containing) is activated in diverse lysosomal disorders, Gaucher disease (30) and mucopolysaccharidosis type IIIA (MPSIIIA) (31), caused by defects in glucosylceramide and heparan sulphate degradation, respectively. Here, NLRP3 is linked to mucopolysaccharidosis type 3A.