TIAM1 and neuropathic pain: To investigate Tiam1’s role in chronic pain–induced depressive-like behaviors, we used the spared nerve injury–induced (SNI-induced) neuropathic pain model and the CFA-induced inflammatory pain model (Figure 1, A and B, and Supplemental Figure 1, A and B; supplemental material available online with this article; https://doi.org/10.1172/JCI158545DS1), which are both well-accepted mouse models of chronic pain (18, 19).