TIAM1 and Anxiety: Strikingly, we found that, in contrast with SNI-treated control mice, Tiam1-cKO mice subjected to SNI did not display depressive- or anxiety-like behaviors in the FST, the TST, the sucrose-preference test (SPT), the EPM test, and the OFA test and instead performed similarly to sham-treated animals (Figure 2, D–H).