Since Paneth cells residing in the small intestinal crypts of Lieberkühn secrete anti-microbial peptides, cytokines, and other trophic factors to maintain balance of the gut microbiota and kill pathogens such as Shigella spp., Salmonella spp., Clostridium difficile, Escherichia coli (E. coli) and Citrobacter rodentium, 2,7,41 we first used Salmonella Typhimurium (S.T) infection models 42 to investigate whether FABP4 can exert roles in controlling infection. Here, FABP4 is linked to infection.