Furthermore, there was a descending tendency in total CD8+ T cell count (CD3+CD4−CD8+) and a growing tendency in cytotoxic CD8+ T cells (CD3+CD4−CD8+CD45RO−CCR7−) counts after BE exposure from HBV-CLD patients (p > .05, Fig. S3B&C). Here, CD8A is linked to congenital secretory chloride diarrhea 1.