In our present study, we found that greater number of electrolyte disorders was associated with a poorer short-term prognosis of ADHF, which may possibly be explained by the fact that patients with greater number of electrolyte disorders usually imply greater severity of HF stage and poorer nutrition status (e.g. higher levels of BNP or NT-proBNP, higher proportions of NYHA IV, and rehospitalizations for HF as well as lower concentrations of serum albumin) [32–35]. The gene discussed is NPPB; the disease is Abnormal blood ion concentration.