ACE2 and infection: Using an in vitro model of infection of cells expressing suboptimal surface ACE2, it was found that the mACE2 variants Asp355Asn, Arg357Ala, and Arg357Thr abrogated entry of SARS-CoV-2 while Tyr41Ala showed only a slight effect on SARS-CoV-2 entry although it inhibited SARS-CoV-1.