ACE2 and cardiac hypertrophy: B38 catalyzes the conversion of Ang II to Ang-(1–7) and can suppress Ang II-induced hypertension, cardiac hypertrophy, and fibrosis in mice does not necessarily mean that the origin of the RAS goes back to bacteria but that a molecule with an ACE2-like carbopeptidase activity was maintained during speciation (Minato et al., 2020).