AGT and Hypertension: Given such encouraging results, it seemed important to design molecules with improved activity against SARS-CoV-2 (Maiti, 2021; Figure 10B) A fusion molecule consisting of murine rACE2 with a Fc fragment (rACE2-Fc), demonstrated a long-lasting ability to protect organs in mice models of Ang II-dependent hypertension (Liu et al., 2018).