Increased circulating levels of Ang II is associated with vasoconstriction and hypertension and accelerates thrombosis in arterioles by activating the coagulation cascade and the platelet-derived growth factor (PDGF; Gustafsson and Holstein-Rathlou, 1999; Heeneman et al., 2000; Senchenkova et al., 2010, 2014; Singh and Karnik, 2016; Samavati and Uhal, 2020). The gene discussed is AGT; the disease is hypertensive disorder.