Moreover, the repression of the Xu and Li, 2021; Figure 5).An in silico studies aimed at predicting miRNAs that regulate ACE2-related networks with a possible impact on COVID-19 outcome, suggests that the top miRNAs regulating ACE2 networks are miR-27a-3p, miR-26b-5p, miR-10b-5p, miR-302c-5p, hsa-miR-587, hsa-miR-1305, hsa-miR-200b-3p, hsa-miR-124-3p, and hsa-miR-16-5p (Wicik et al., 2020). This evidence concerns the gene ACE2 and COVID-19.