Due to the central role played by ACE2 in maintaining blood pressure homeostasis, the objective of this work is to review the state of knowledge regarding the possible imbalance of the RAS in the context of a SARS-CoV-2 infection and to highlight the role of ACE2 in SARS-CoV-2 infection and replication, as well as its contribution in the severity of COVID-19. This evidence concerns the gene ACE2 and COVID-19.