Tissue transglutaminase (TG2)-mediated modification of AT1R contributes to AT1R auto-antibody production and hypertension associated with preeclampsia; the post-translational modification of Gln187 in the second extracellular loop of the AT1R loop creates a neo-epitope that induces the production of an autoantibody that can activate the receptor (Liu et al., 2015). This evidence concerns the gene TGM2 and hypertensive disorder.