In the plasma of prolonged viral shedders, we also found higher concentrations of Ang II and Ang I. However, the plasma levels of Ang-(1–7) were found to be almost stable in prolonged viral shedders, but seemed insufficient to prevent the adverse effects of Ang II accumulation, strongly suggesting that increased levels of Ang II contribute to thrombotic events associated with the severe forms of COVID-19. Here, AGT is linked to COVID-19.