Moreover, a low expression of ACE2 mRNA or protein is associated with an increase in AngII levels, hypertension, diabetes and heart disease (Crackower et al., 2002; Diez-Freire et al., 2006; Tikellis et al., 2012; Velkoska et al., 2016).Interestingly, these diseases are the major comorbidities in the severe forms of COVID-19 (Bavishi et al., 2020). The gene discussed is AGT; the disease is COVID-19.