REN and Hypertension: These AT1R-mediated signals lead to overexpression of the prorenin receptor (PRR), thereby increasing renin activity and contributing to the local accumulation of Ang II, fibrosis, and hypertension (Nguyen et al., 2002; Advani et al., 2009; Peng et al., 2013; Wang et al., 2014; Xu et al., 2016; Ichihara and Yatabe, 2019).