G. lucidum polysaccharides significantly increased the relative abundance of Ligilactobacillus, Bifidobacterium, and SCFAs in the intestine of colitis mice, by activating G-protein-coupled receptor 43 (GPR43) in gut immune cells and eliciting anti-inflammatory and tumor immunoregulatory effects (Guo et al., 2021). Here, FFAR2 is linked to colitis.