Previously, comparing the blood expression levels of BDNF between 22 controls and 62 manifest gene carriers from this cohort using RNAseq, we found that Huntington’s disease gene carriers had lower levels of BDNF expression than controls (P = 0.04266).48 Post-mortem studies have also identified reduced BDNF levels in the striatum of Huntington’s disease patients. The gene discussed is BDNF; the disease is Huntington disease.