The roles of p53 in BC tumor microenvironment is also noted, among which of the most discussed is p53 and its association with NF-kB.Nuclear Factor-kappa Beta (NFKB) is a transcription factor family consisting of 5 subtypes: p50, p52, p65 (RelA), RelB, and c-Rel. The gene discussed is RELA; the disease is neoplasm.