Based on these results, we found that QHZYF might attenuate atherosclerosis via targeting PPARγ-mediated PPARγ/LXRα/ABCA1-ABCG1 and PPARγ/NF-κB p65 pathways to regulate cholesterol efflux and endothelial inflammation. This evidence concerns the gene NFKB1 and atherosclerosis.