Based on these results, we found that QHZYF might attenuate atherosclerosis via targeting PPARγ-mediated PPARγ/LXRα/ABCA1-ABCG1 and PPARγ/NF-κB p65 pathways to regulate cholesterol efflux and endothelial inflammation. The gene discussed is NR1H3; the disease is atherosclerosis.