In conclusion, our study revealed that QHZYF could attenuate atherosclerosis via targeting PPARγ-mediated PPARγ/LXRα/ABCA1-ABCG1 and PPARγ/NF-κB p65 pathways to regulate cholesterol efflux and endothelial cell inflammatory response, providing direct and sufficient evidence for the treatment of atherosclerosis with TCM. Here, PPARG is linked to atherosclerosis.