Based on the above results, this study confirmed that QHZYF could attenuate atherosclerosis via targeting PPARγ-mediated PPARγ/LXRα/ABCA1-ABCG1 and PPARγ/NF-κB p65 pathways to regulate cholesterol efflux and endothelial cell inflammatory response. Here, ABCA1 is linked to atherosclerosis.