CD4 and neoplasm: The CD4+Th1/CD4+Th2 balance plays an important role in the tumor microenvironment (Ruterbusch et al., 2020), and our results showed that high expression of RIOK2 was negatively correlated with CD4+Th1/CD4+Th2 cells, indicating that RIOK2 is involved in Th1/Th2 regulation (Figure 7C).