Interestingly, RIOK2 expression in malignant tissues was lower than that in healthy tissues, as was the case for lung squamous cell carcinoma (LUSC), kidney renal papillary cell carcinoma (KIRP), kidney chromophobe (KICH), uterine corpus endometrial carcinoma (UCEC), and thyroid carcinoma (THCA) (Figures 1A,B, Wilcoxon p-value < 0.05). This evidence concerns the gene RIOK2 and squamous cell lung carcinoma.