According to the regression curves (Supplementary Figure S1A), RIOK2 mRNA was enriched in adrenocortical carcinoma, brain LGG, and skin cutaneous melanoma (SKCM) with an increasing level of tumor purity (Figure 1C), indicating that elevated or decreased RIOK2 expression in most tumors partly originated from tumor cells and partly from non-tumor cells. The gene discussed is RIOK2; the disease is cutaneous melanoma.