Evidence has accumulated that RIOK2 is connected with diverse cellular processes in cancer development and progression, such as cellular proliferation, migration, invasion, and apoptosis (Liu et al., 2016; Liu et al., 2018; Delman et al., 2019; Mohamed et al., 2018; Read et al., 2013; Song et al., 2020) For example, RIOK2 promotes glioma cell migration and invasion through epithelial–mesenchymal transition (Ameismeier et al., 2020). The gene discussed is RIOK2; the disease is central nervous system cancer.