In addition, in the case of KICH, KIRP, LICH, LUSC, ovarian serous cystadenocarcinoma (OV), clear cell renal cell carcinoma (ccRCC), LUAD, and UCEC, RIOK2 mRNA expression was lower in healthy tissue and increased with pathological stage, with the highest levels observed in invasive cancer samples (Figure 2B, p < 0.05). This evidence concerns the gene RIOK2 and clear cell renal carcinoma.