Interestingly, positive correlations between RIOK2 mRNA and nodal metastatic status were established in six different cancer types, namely adrenocortical carcinoma, breast invasive carcinoma (BRCA), KICH, COAD, KIRC, and THCA (Figure 2A, p < 0.05). The gene discussed is RIOK2; the disease is invasive breast carcinoma.