RIOK2 mRNA levels were elevated in most tumor types, with the highest levels detected in cholangiocarcinoma (CHOL), diffuse large B-cell lymphoma (DLBC), thymoma (THYM), glioblastoma multiforme (GBM), brain lower-grade glioma (LGG), and pancreatic adenocarcinoma (PAAD), followed by colon adenocarcinoma (COAD), liver hepatocellular carcinoma (LIHC), kidney renal clear cell carcinoma (KIRC), head and neck squamous cell carcinoma (HNSC), stomach adenocarcinoma (STAD), and esophageal carcinoma (ESCA). Here, RIOK2 is linked to diffuse large B-cell lymphoma.