Four out of 19 (21 %) tumor samples did not show any specific immunoreactivity, while in 15/19 (79 %) fibropapillomas, MMP-2 was expressed in the cytoplasm of basal, spinosum and granular epithelial layers, although a weaker immunoreactivity was noted in the basal cell layer (Figure 2B). Here, MMP2 is linked to neoplasm.