In the context of liver cancer, the role of ASGR1 as tumor suppressor was first suggested via its interaction with LASS2 (longevity assurance homolog 2 of yeast LAG1) (Gu et al., 2016) and more recently by its association with DNA methylation (Zhu et al., 2022), confirming the prior findings of loss of ASGR1 expression in HCC tissue (Shi et al., 2013; Witzigmann et al., 2016). Here, ASGR1 is linked to liver cancer.