Other roles of ASGR1 such as hepatitis C virus binding allowing viral infection (Saunier et al., 2003) or metastasis promotion by interaction with lectins in the tumor microenvironment through the EGFR-ERK pathway (Ueno et al., 2011) are also described in relation with HCC induction. The gene discussed is EGFR; the disease is hepatocellular carcinoma.