Surprisingly, cKit- FcεRI+ basophils in the acute colitis exclusively increased up to 58.1% in AKR1B10 KO mice vs. 1.4% in wild type (Figure 2D); the absolute number of cKit- FcεRI+ basophils increased over 100 times in AKR1B10 KO mice compared to wild type (Figure 2D, right panel)). This evidence concerns the gene AKR1B10 and colitis.