With 5.4 x 105 pfu HSV-1, corneal opacity in the WT mice rapidly resolved at 1week p.i. with near complete restoration of corneal clarity, whereas in ACKR2-/- mice, HSK was significantly prolonged with higher corneal opacity scores at day 7 and 14 p.i. (Figure 1A). This evidence concerns the gene ACKR2 and Corneal opacity.