It is supposed that the dysregulation or dysfunction of LRPPRC may play critical roles in diseases caused by PI3K/AKT/mTOR and JAK/STAT pathway dysregulation (Cui, Wang et al., 2019), including IPF (Woodcock, Eley et al., 2019; Montero, Milara et al., 2021; Wasnick, Korfei et al., 2022). The gene discussed is SOAT1; the disease is idiopathic pulmonary fibrosis.