It is known that steady-state potassium currents are decreased in ALS motor neurons and that the activation of Kv7.2/7.3, a potassium channel encoded by KCNQ2 and KCNQ3 and a main component of the neuron M-current, can stabilize membrane potential and block neuron hyperexcitability. Here, KCNQ2 is linked to amyotrophic lateral sclerosis.