Warner et al13 compared the expression levels of snoRNA in 33 cases of acute myeloid leukemia (AML) and 6 normal blood samples, and found that a series of snoRNA molecules were abnormally expressed in AML patients, of which 37 snoRNAs were located in the DLK1-DIO3 or SNURF-SNRPN imprinted regions. This evidence concerns the gene DIO3 and acute myeloid leukemia.