Previous studies showed that sequence analysis of antipneumococcal PS Abs, 5 days postvaccination; demonstrated a predominance of IgG and IgA, which are presumably derived from switched memory cells that have undergone somatic hypermutation.37,38 Also in mice, the B1b cell subset participated in IgM and isotype-switched antibody production in response to pneumococcal PS.39 Raised IgE level in children with SCD postvaccination might be an indication of continuous inflammation in children with SCD with Prevenar pneumococcal vaccine. The gene discussed is CD40LG; the disease is Schnyder corneal dystrophy.