Inhibiting FTO by R-2HG was found increasing the overall level of m6A without affecting FTO expression and decreasing the stability of MYC and CEBPA mRNA in R-2HG-sensitive leukemia cells.65 R-2HG also abrogates FTO/m6A/YTHDF2-mediated upregulation of 2 critical glycolytic genes phosphofructokinase platelet (PFKP) and lactate dehydrogenase B (LDHB), thereby suppressing the glycolysis of leukemia cells.66 The gene discussed is MYC; the disease is leukemia.