Promoter-bound METTL3 recruits CEBPZ and regulates the translation of downstream oncogenic drivers SP1 and SP2, subsequently regulating the expression of c-MYC.68 METTL14 exerts its oncogenic role by regulating MYB and MYC mRNA degradation and translation through m6A modification, and also plays a critical role in AML development and maintenance.69 WTAP was found overexpressed in AML patients, which are inversely correlated with overall survival in patients with AML. The gene discussed is MYB; the disease is acute myeloid leukemia.