Promoter-bound METTL3 recruits CEBPZ and regulates the translation of downstream oncogenic drivers SP1 and SP2, subsequently regulating the expression of c-MYC.68 METTL14 exerts its oncogenic role by regulating MYB and MYC mRNA degradation and translation through m6A modification, and also plays a critical role in AML development and maintenance.69 WTAP was found overexpressed in AML patients, which are inversely correlated with overall survival in patients with AML. This evidence concerns the gene SP1 and acute myeloid leukemia.