For instance, translocations of MLL, encoding a histone methyltransferase, are recurrently found in chromosomal rearrangements involving 11q23 in AML, highlighting the significance of this epigenetic modifying enzyme in AML development.13 Other histone modification enzymes, such as DOT1L, EZH2, ASXL1, KDM1A, also involve in leukemogenesis by providing a selective advantage to LSCs.14–17. Here, DOT1L is linked to acute myeloid leukemia.