Mechanistically, YTHDC1 regulates leukemogenesis through MCM4, which is a critical regulator of DNA replication.73 YTHDF2 deletion extends the half-life of m6A-modified transcripts including Tnfrsf2 to selectively compromise AML initiation and propagation without harming normal hematopoiesis.74 Recently, we reported that YBX1 interacts with IGF2BPs to stabilize m6A-modified transcripts, including MYC and BCL2. The gene discussed is YTHDF2; the disease is acute myeloid leukemia.