Numerous studies have shown that methyltransferase complex components (METTL3, METTL14, WTAP), demethylases (FTO, ALKBH5), and the m6A binding protein (YTHDF2, YTHDC1, and IGF2BPs) are all highly expressed in AML. This evidence concerns the gene METTL14 and acute myeloid leukemia.