Deletion of IGF2BP1 affects proliferation, promotes myeloid differentiation, and decreases tumorigenic potential of AML cells by regulating HOXB4, MYB, and ALDH1A1.76 IGF2BP3 is also required for AML cell survival in an m6A-dependent manner, and IGF2BP3 loss significantly induces AML cell apoptosis, inhibits proliferation, and attenuates the ability of AML cells to develop leukemia in vitro and in vivo. The gene discussed is IGF2BP3; the disease is leukemia.