MEG3 and neoplasm: Downregulation of microRNA-374b had a close relationship with the development and drug-resistance of T-LBL.41 Additionally, microRNA-211, a tumor suppressor, targets TCF12 to reduce viability and DNA synthesis of T-LBL cells.42 But microRNA-21 was upregulated in tumor tissues of T-LBL/ALL as a pro-oncogenic factor.43 Besides, maternally expressed gene 3 (MEG3), a long noncoding RNA, suppressed cell migration, invasion, and drug-resistance by suppressing PI3K/mTOR signaling pathway in T-LBL.44