CASP8AP2 and hematopoietic and lymphoid system neoplasm: LOH6q is possibly related to loss of the important tumor-suppressor genes, which have been found in solid tumors and hematologic neoplasms.31 LOH6q is detected in 19% of patients with T-LBL, and affects the caspase 8-associated protein 2 gene (CASP8AP2).32 CASP8AP2 participates in programmed cell death mediated by the FAS signaling pathway and tumor necrosis factor α (TNFα), transcription regulation by c-Myb and corticoid receptor.33 Moreover, LOH6q is also correlated with the increased risk of recurrence and unfavorable clinical outcome of T-LBL.34