As a negative regulator of antiviral signaling, KHSRP associates with the regulatory domain of RIG-I, reduces vital RNA associations with RIG-I during viral infection, and represses RIG-I activation.47 Moreover, KHSRP has been described as a direct negative regulator of type I IFN mRNA stability,48 and deletion of its expression leads to T-cell defects.25 By combining KHSRP eCLIP-seq and RNA-seq data from monocytes in this study, we showed that KHSRP modulates the alterative splicing of several essential monocytic genes, such as PTK2B, PUM1, and LMO2. Here, KHSRP is linked to viral infectious disease.