PUM1 and viral infectious disease: As a negative regulator of antiviral signaling, KHSRP associates with the regulatory domain of RIG-I, reduces vital RNA associations with RIG-I during viral infection, and represses RIG-I activation.47 Moreover, KHSRP has been described as a direct negative regulator of type I IFN mRNA stability,48 and deletion of its expression leads to T-cell defects.25 By combining KHSRP eCLIP-seq and RNA-seq data from monocytes in this study, we showed that KHSRP modulates the alterative splicing of several essential monocytic genes, such as PTK2B, PUM1, and LMO2.